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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Galiellalactone/6218/500U/500 ug
产品编号:6218
市  场 价:¥4300.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$215.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Galiellalactone/6218/500U/500 ug
商品介绍
Description:STAT3inhibitor;activeinvivo
ChemicalName:(4S,5aR,7aR,7bS)-5,5a,6,7,7a,7b-Hexahydro-7b-hydroxy-4-methylindeno[1,7-bc]furan-2(4H)-one
Purity:≥95%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

STAT3inhibitor.IrreversIBLybindsSTAT3andinhibitsbindingtoDNA.InhibitsIL-6-dependentJAK/STATsignaling.Inducescell-cyclearrestinG2/Mphaseandapoptosisinandrogen-insensitiveprostatecancercellsviaactivationofATM/ATRpathway.AlsodestABIlizesmicrotubulesandinhibitscellmigration.Exhibitsanticancereffectsinamousetumorxenograftmodel.

TechnicalData

M.Wt194.23
FormulaC11H14O3
StorageStoreat-20°C
Purity≥95%(HPLC)
CASNumber133613-71-5
PubChemID3698011
InChIKeySOIISBQQYAGDKM-UHFFFAOYSA-N
Smiles[H][C@@]12CC[C@]3(OC(C([C@@]23O)=C[C@H](C1)C)=O)[H]

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO0.975
ethanol0.975

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight194.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM5.15mL25.74mL51.49mL
5mM1.03mL5.15mL10.3mL
10mM0.51mL2.57mL5.15mL
50mM0.1mL0.51mL1.03mL