STAT3inhibitor.IrreversIBLybindsSTAT3andinhibitsbindingtoDNA.InhibitsIL-6-dependentJAK/STATsignaling.Inducescell-cyclearrestinG2/Mphaseandapoptosisinandrogen-insensitiveprostatecancercellsviaactivationofATM/ATRpathway.AlsodestABIlizesmicrotubulesandinhibitscellmigration.Exhibitsanticancereffectsinamousetumorxenograftmodel.
M.Wt | 194.23 |
Formula | C11H14O3 |
Storage | Storeat-20°C |
Purity | ≥95%(HPLC) |
CASNumber | 133613-71-5 |
PubChemID | 3698011 |
InChIKey | SOIISBQQYAGDKM-UHFFFAOYSA-N |
Smiles | [H][C@@]12CC[C@]3(OC(C([C@@]23O)=C[C@H](C1)C)=O)[H] |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 0.97 | 5 | |
ethanol | 0.97 | 5 |
Thefollowingdataisbasedontheproductmolecularweight194.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 5.15mL | 25.74mL | 51.49mL |
5mM | 1.03mL | 5.15mL | 10.3mL |
10mM | 0.51mL | 2.57mL | 5.15mL |
50mM | 0.1mL | 0.51mL | 1.03mL |
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.