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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Nanchangmycin/6183/10/10 mg
产品编号:6183
市  场 价:¥5180.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$259.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Nanchangmycin/6183/10/10 mg
商品介绍
Description:Antiviral;activeagainstZika,WestNileanddengueviruses
ChemicalName:(2S,4R,6E,8S)-8-[(2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-Hydroxy-2,4',8,10'-tetramethyl-2'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9'-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7'-bi-1,6-dioxaspiro[4.5]dec]-7-yl]-2,4,6-trimethyl-5-oxo-6-nonenoicacidsodiumsalt
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Antiviral.InhibitsZikavirusentryinarangeofcelltypesincludingprimaryplacentalfibroblastcells,HUVECsandUtMECs(IC50valuesare0.1,0.4and0.97μMinU2OS,HBMECsandJeg-3cellsrespectively).AlsoinhibitscellularuptakeofWestNile,dengue,sindbisandchikungunyaviruses.

TechnicalData

M.Wt889.1
FormulaC47H77NaO14
StorageStoreat-20°C
CASNumber65101-87-3
PubChemID46930988
InChIKeyXMAIRYYXDCNFKP-DYTQFKGPSA-M
Smiles[H][C@]1([C@]2(O[C@@](CO)([C@@H](C[C@@H]2C)C)O)[H])C[C@@H]([C@@]3(O[C@](C[C@@H]([C@H]3C)O[C@@]4(CC[C@@H]([C@H](O4)C)OC)[H])([C@@]5(CC[C@@]6(O5)C[C@@H]([C@H]([C@](O6)([C@H](/C=C(C([C@@H](C[C@@H](C(O[Na])=O)C)C)=O)C)C)[H])C)O)C)[H])O1)C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO88.91100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight889.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.12mL5.62mL11.25mL
5mM0.22mL1.12mL2.25mL
10mM0.11mL0.56mL1.12mL
50mM0.02mL0.11mL0.22mL