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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/MK 386/5842/1/1 mg
产品编号:5842
市  场 价:¥3580.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$179.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/MK 386/5842/1/1 mg
商品介绍
Description:Potent,selectivehumantype15α-reductaseinhibitor
ChemicalName:(4aR,4bS,6aR,7R,9aS,9bS,10S,11aR)-7-[(1R)-1,5-Dimethylhexyl]hexadecahydro-1,4a,6a,10-tetramethyl-2H-indeno[5,4-f]quinolin-2-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectivehumantype15α-reductaseinhibitor(5αR1,IC50=0.9nM).Exhibits100-foldselectivityfor5αR1over5αR2(IC50=154nM).Supresseshumanserumandsebumdihydrotestosterone(DHT)levelsinadose-dependentmannerwithoutaffectingsemenDHTconcentrations.Orallyactive.

TechnicalData

M.Wt415.69
FormulaC28H49NO
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber158493-17-5
PubChemID178013
InChIKeyXUTZDXHKQDPUMA-UHFFFAOYSA-N
Smiles[H][C@]1([C@@H](CCCC(C)C)C)CC[C@]2([C@@]3([C@H](C[C@]4(N(C(CC[C@@]4([C@]3(CC[C@]12C)[H])C)=O)C)[H])C)[H])[H]

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO41.57100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight415.69.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.41mL12.03mL24.06mL
5mM0.48mL2.41mL4.81mL
10mM0.24mL1.2mL2.41mL
50mM0.05mL0.24mL0.48mL