Nurr1activator.InhibitsNF-κBandcytokineexpressioninmicroglialcellsbystABIlizingnuclearcorepressorproteins,whichreducesbindingofp65toinflammatorygenepromoters.NeuroprotectiveinamouseParkinson'sdiseasemodel.Orallybioavailable.
M.Wt | 356.85 |
Formula | C23H17ClN2 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 178946-89-9 |
PubChemID | 5302583 |
InChIKey | LTLRXTDMXOFBDW-UHFFFAOYSA-N |
Smiles | ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 35.69 | 100 | |
ethanol | 35.69 | 100 |
Thefollowingdataisbasedontheproductmolecularweight356.85.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.8mL | 14.01mL | 28.02mL |
5mM | 0.56mL | 2.8mL | 5.6mL |
10mM | 0.28mL | 1.4mL | 2.8mL |
50mM | 0.06mL | 0.28mL | 0.56mL |
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.