Syntheticprogesteroneanalog.Dose-dependentlyinhibitsgrowthofHepG2cells(IC50=260μM)invitroandinvivoandreducestumorvolume.Highdosagesimproveweightgainintumor-bearingnudemice.Orallybioavailable.
M.Wt | 384.51 |
Formula | C24H32O4 |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 595-33-5 |
PubChemID | 11683 |
InChIKey | RQZAXGRLVPAYTJ-GQFGMJRRSA-N |
Smiles | [H][C@@]12CC[C@](C(C)=O)([C@]1(CC[C@]3([C@]2(C=C(C4=CC(CC[C@]34C)=O)C)[H])[H])C)OC(C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 19.23 | 50 | |
ethanol | 7.69 | 20 |
Thefollowingdataisbasedontheproductmolecularweight384.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.6mL | 13mL | 26.01mL |
5mM | 0.52mL | 2.6mL | 5.2mL |
10mM | 0.26mL | 1.3mL | 2.6mL |
50mM | 0.05mL | 0.26mL | 0.52mL |
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.