Thalidomideanalog.Immunemodulatorydrugandcereblonbindingcompound.Inducesubiquitinationanddegradationofcaseinkinase(CK)1αbytheE3ubiquitinligaseCRL4CRBN.AlsoTNF-αinhibitorandangiogenesisinhibitor.
M.Wt | 259.26 |
Formula | C13H13N3O3 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 191732-72-6 |
PubChemID | 216326 |
InChIKey | GOTYRUGSSMKFNF-UHFFFAOYSA-N |
Smiles | NC1=C2CN(C(C2=CC=C1)=O)C3CCC(NC3=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 25.93 | 100 |
Thefollowingdataisbasedontheproductmolecularweight259.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.86mL | 19.29mL | 38.57mL |
5mM | 0.77mL | 3.86mL | 7.71mL |
10mM | 0.39mL | 1.93mL | 3.86mL |
50mM | 0.08mL | 0.39mL | 0.77mL |
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.