PotentTNF-αinhibitor(IC50=13nM).AlsopotentlyinhibitsIL-2(EC50=8nM).Thalidomidederivative.Bindscereblonandinhibitsitsubiquitination.ExhibitsantiproliferativeeffectsinaNamalwalymphomacellline.Antiangiogenic.
M.Wt | 273.24 |
Formula | C13H11N3O4 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 19171-19-8 |
PubChemID | 134780 |
InChIKey | UVSMNLNDYGZFPF-UHFFFAOYSA-N |
Smiles | NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 27.32 | 100 |
Thefollowingdataisbasedontheproductmolecularweight273.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.66mL | 18.3mL | 36.6mL |
5mM | 0.73mL | 3.66mL | 7.32mL |
10mM | 0.37mL | 1.83mL | 3.66mL |
50mM | 0.07mL | 0.37mL | 0.73mL |
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.