PotentHDAC6inhibitor(IC50=0.015μM).ExhibitssomeselectivelyforHDAC6overHDAC8and1(IC50valuesare0.854and16.4μM,respectively).Induceselevatedlevelsofα-tubulinandprotectsagainstglutathione-inducedoxidativestressinprimaryneuronalcellculture.
M.Wt | 371.86 |
Formula | C20H21N3O2.HCl |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 1310693-92-5 |
PubChemID | 57336514 |
InChIKey | LJTSJTWIMOGKRJ-UHFFFAOYSA-N |
Smiles | CN1CCC2=C(C3=CC=CC=C3N2CC4=CC=C(C(NO)=O)C=C4)C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 3.72 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight371.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.69mL | 13.45mL | 26.89mL |
5mM | 0.54mL | 2.69mL | 5.38mL |
10mM | 0.27mL | 1.34mL | 2.69mL |
50mM | 0.05mL | 0.27mL | 0.54mL |
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.