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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/TH 1020/6191/10/10 mg
产品编号:6191
市  场 价:¥2500.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$125.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/TH 1020/6191/10/10 mg
商品介绍
Description:Toll-likereceptor(TLR)5/FlagellincomplexantagoNIST
ChemicalName:4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Toll-likereceptor(TLR)5/Flagellincomplexantagonist(IC50=0.85μM).CompeteswithflagellinforTLR5bindingtoinhibittheTLR5:flagellininteractionandsubsequentdownstreamTNF-αsecretion.

TechnicalData

M.Wt453.54
FormulaC23H15N7S2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber1841460-82-9
PubChemID124203921
InChIKeyCBBXTGWSGPEJEE-UHFFFAOYSA-N
SmilesN1(C(SC2=C3SC4=NC=CC=C4C3=NC=N2)=NN=C1C5=CC=NC=C5)CC6=CC=CC=C6

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO2.275mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight453.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.2mL11.02mL22.05mL
5mM0.44mL2.2mL4.41mL
10mM0.22mL1.1mL2.2mL
50mM0.04mL0.22mL0.44mL