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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/IN 1130/6016/5/5 mg
产品编号:6016
市  场 价:¥2180.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$109.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/IN 1130/6016/5/5 mg
商品介绍
Description:PotentandselectiveinhibitorofTGF-βRI
ChemicalName:3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveinhibitorofTGF-βtypeIreceptor(ALK5).InhibitsSmad-2phosphorylation(IC50=5.3nM).Exhibitsselectivityoverapanelof27serine/threonineandtyrosinekinasesincludingP38α.AttenuatesTGFβ/Smadsignaling,cellmigration,invasion,lungmetastasisandincreasessurvivalofmicein4TIinvivomodels.Suppressesrenalfibrosisinobstructivenephropathyinvivomodels.

TechnicalData

M.Wt420.47
FormulaC25H20N6O
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber868612-83-3
PubChemID11676119
InChIKeyRYKSGWSKILPDDY-UHFFFAOYSA-N
SmilesCC1=NC(C2=C(C3=CC4=C(N=CC=N4)C=C3)NC(CC5=CC(C(N)=O)=CC=C5)=N2)=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.HCl42.05100
DMSO42.05100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight420.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.38mL11.89mL23.78mL
5mM0.48mL2.38mL4.76mL
10mM0.24mL1.19mL2.38mL
50mM0.05mL0.24mL0.48mL