SelectiveRev-Erbα/βagonist(IC50valuesare160and170nMforRev-ErbβandRev-Erbαrespectively).Exhibitsnosignificantactivityagainstawiderangeofnuclearreceptors,otherreceptors,ionchannelsandtransportersat20μM.Increaseswakefulness,reducesREMandslowwavesleepinvivo.Alsoreducesanxiety-likebehaviorinmarble-buryingassay.Cellpermeableandbrainpenetrant.
M.Wt | 465.58 |
Formula | C31H31NO3 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 1380548-02-6 |
Smiles | CC(C)(OC1=CC=C(C=C1)OCC2CC3=CC=CC=C3CN2C(C4=CC=CC5=C4C=CC=C5)=O)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 2.33 | 5mMwithgentlewarming | |
ethanol | 2.33 | 5mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight465.58.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.15mL | 10.74mL | 21.48mL |
5mM | 0.43mL | 2.15mL | 4.3mL |
10mM | 0.21mL | 1.07mL | 2.15mL |
50mM | 0.04mL | 0.21mL | 0.43mL |
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.