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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/M62812/5705/10/10 mg
产品编号:5705
市  场 价:¥2300.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$115.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/M62812/5705/10/10 mg
商品介绍
Description:TLR-4inhibitor
ChemicalName:6-(2-Aminophenoxy)-1,2-benzisothiazol-3-aminedihydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

TLR4inhibitor.InhibitsLPS-inducedNF-κBactivationinHEK293cells(IC50=2.4μg/mL).AlsoinhibitsLPS-inducedcytokineproductionandprocoagulanteffectsinPBMCsandHUVECs.Prolongssurvivalinamousesepticshockmodel.

TechnicalData

M.Wt330.23
FormulaC13H11N3OS.2HCl
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber613263-00-6
PubChemID44224214
InChIKeySMTKPLISDFNJDJ-UHFFFAOYSA-N
SmilesNC1=CC=CC=C1OC2=CC=C3C(SN=C3N)=C2.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO16.5150
water33.02100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight330.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.03mL15.14mL30.28mL
5mM0.61mL3.03mL6.06mL
10mM0.3mL1.51mL3.03mL
50mM0.06mL0.3mL0.61mL