Potentandselectivelysosomalacidlipase(LAL)inhibitor(IC50=68nM).Exhibitsnosignificantactivityagainstpancreaticlipaseorlipoproteinlipaseat10μMconcentration.BlocksLAL-mediatedlipidhydrolysisofacetylatedLDLandreduceseffluxofcholesterolfromlipid-loadedcellsresultinginincreasedcellularcholesterolesterlevels.
M.Wt | 298.36 |
Formula | C12H18N4O3S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 501104-16-1 |
PubChemID | 648404 |
InChIKey | GKOPFXFKPASEFI-UHFFFAOYSA-N |
Smiles | O=C(OC1=NSN=C1N2CCCCC2)N3CCOCC3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 29.84 | 100 | |
ethanol | 29.84 | 100 |
Thefollowingdataisbasedontheproductmolecularweight298.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.35mL | 16.76mL | 33.52mL |
5mM | 0.67mL | 3.35mL | 6.7mL |
10mM | 0.34mL | 1.68mL | 3.35mL |
50mM | 0.07mL | 0.34mL | 0.67mL |
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.