Potentandselectivehemeoxygenase1(HO-1)inhibitor(IC50valuesare1.9and>100μMforHO-1andHO-2respectively),reducesproteincarbonylationandreactiveoxygenspeciesformationinadvancedprostatecancercells(PCA).InhibitscellproliferationinvitroandPCAtumorgrowthandlymphnode/lungmetastasesinvivo.SynergizeswithTaxol(Cat.No.1097).
| M.Wt | 373.67 |
| Formula | C15H17BrN2O2.HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 939825-12-4 |
| PubChemID | 45265865 |
| InChIKey | YSOWYXRHOAXXTG-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(C=C1)CCC2(OCCO2)CN3C=CN=C3.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.37 | 100 | |
| water | 37.37 | 100 |
Thefollowingdataisbasedontheproductmolecularweight373.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.68mL | 13.38mL | 26.76mL |
| 5mM | 0.54mL | 2.68mL | 5.35mL |
| 10mM | 0.27mL | 1.34mL | 2.68mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.