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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/FPS ZM1/6237/10/10 mg
产品编号:6237
市  场 价:¥1300.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$65.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/FPS ZM1/6237/10/10 mg
商品介绍
Description:HighaffinityantagoNISTofRAGE
ChemicalName:4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Highaffinityantagonistofthereceptorforadvancedglycationendproducts(RAGE)(Ki=25nM).BlocksAβbindingtotheVdomainofRAGEandinhibitsAβ40-andAβ42-inducedcellularstressinRAGE-expressingcellsinvitroandinthemousebraininvivo.Blocksβ-secretaseactivity,Aβproduction,microgliaactivationandneuroinflammationinvivo.BBBpermeable.

TechnicalData

M.Wt327.85
FormulaC20H22ClNO
StorageStoreat-20°C
Purity≥99%(HPLC)
CASNumber945714-67-0
PubChemID24752728
InChIKeyXDFKWGIBQMHSOH-UHFFFAOYSA-N
SmilesClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO32.78100
ethanol32.78100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight327.85.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.05mL15.25mL30.5mL
5mM0.61mL3.05mL6.1mL
10mM0.31mL1.53mL3.05mL
50mM0.06mL0.31mL0.61mL