Potentandselectiveκ-opioidDREADD(KORD)activator(EC50=11.8nM).SelectiveforKORDoverendogenousκopioidreceptorandarangeofotherrelatedtargets.Exhibitsnoanalgesicorataxiceffectsinwildtypemice.Inducesneuronalhyperpolarization,andmodifieslocomotoractivityandfeedingbehaviorinKORD-expressingmousemodels.Brainpenetrant.MetaboliteofsalvinorinA(Cat.No.2134).
M.Wt | 390.43 |
Formula | C21H26O7 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 92545-30-7 |
PubChemID | 11440685 |
InChIKey | BLTMVAIOAAGYAR-CEFSSPBYSA-N |
Smiles | O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](O)C1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 7.81 | 20 |
Thefollowingdataisbasedontheproductmolecularweight390.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.56mL | 12.81mL | 25.61mL |
5mM | 0.51mL | 2.56mL | 5.12mL |
10mM | 0.26mL | 1.28mL | 2.56mL |
50mM | 0.05mL | 0.26mL | 0.51mL |
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.