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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Clozapine N-oxide/4936/10/10 mg
产品编号:4936
市  场 价:¥2780.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$139.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Clozapine N-oxide/4936/10/10 mg
商品介绍
Description:ActivatorofmuscarinicDREADDs
ChemicalName:8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Metaboliteofclozapine(Cat.No.0444).Activateshumanmuscarinicdesignerreceptors(DREADDs)invitro.SilenceshippocampalneuronsexpressinghM4DREADDsinvitro.ActivatesGs-linkedDREADDS-AgRPinmiceviaintracerebroventricular(i.c.v)injection.ShowntobeaP-glycoprotein(P-gp)effluxpumpsubstrate.OtherpotentandselectivehM3DqDREADDagoNISTsavailable:DREADDagonist21(Cat.No.5548)andPerlapine(Cat.No.5549)

TechnicalData

M.Wt342.82
FormulaC18H19ClN4O
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber34233-69-7
PubChemID2819
InChIKeyWYRDWWAASBTJLM-UHFFFAOYSA-N
SmilesClC(C=C3)=CC1=C3NC(C=CC=C2)=C2C(N4CC[N+](C)([O-])CC4)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO6.8620
ethanol3.4310mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight342.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.92mL14.58mL29.17mL
5mM0.58mL2.92mL5.83mL
10mM0.29mL1.46mL2.92mL
50mM0.06mL0.29mL0.58mL