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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SCR7 pyrazine/5342/10/10 mg
产品编号:5342
市  场 价:¥3980.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$199.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SCR7 pyrazine/5342/10/10 mg
商品介绍
Description:EnhancesHDRefficiency
ChemicalName:2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

EnhancesCRISPR-Cas9-mediatedhomology-directedrepair(HDR)efficiencyinvitroupto19-fold.Inhibitsnonhomologousend-joining(NHEJ).

WehavediscoveredthatthecommerciallyavailableSCR7materialsuppliedbyothervendorsdoesnotmatchthechemicalstructurethatitisbeingsoldunder.ThroughdetailedchemicalanalysiscarriedoutbyourAnalyticalQualityControlexperts,webelievethatthecommerciallyavailableSCR7material,includingthatusedinrecentpublicationstoenhanceCRISPRefficiency,isinfactananalogofSCR7thatwehavenamed'SCR7pyrazine'.

ViewmoreinformationregardingthestructureofSCR7.

TechnicalData

M.Wt332.38
FormulaC18H12N4OS
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber14892-97-8
PubChemID10688007
InChIKeyGSRTWXVBHGOUBU-UHFFFAOYSA-N
SmilesO=C(C(N=C(C3=CC=CC=C3)C(C4=CC=CC=C4)=N2)=C2N1)NC1=S

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO33.44100
ethanol6.6920

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight332.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.01mL15.04mL30.09mL
5mM0.6mL3.01mL6.02mL
10mM0.3mL1.5mL3.01mL
50mM0.06mL0.3mL0.6mL