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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SR 1664/4409/10/10 mg
产品编号:4409
市  场 价:¥3780.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$189.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SR 1664/4409/10/10 mg
商品介绍
Description:HighaffinityPPARγligand;blocksCdk5-dependentPPARγphosphorylation
ChemicalName:4'-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylicacid
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Antidiabeticagent;bindstoPPARγandpotentlyinhibitsCdk5-mediatedPPARγphosphorylation(IC50=80nM;Ki=28.67nM)withoutexhibitingPPARγagoNISTactivity.DoesnotinhibitCdk5-dependentphosphorylationofRb.Reducesfastinginsulinlevelsandimprovesinsulinsensitivityinamousemodelofdiabetes.

CompoundLibraries

SR1664isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt547.6
FormulaC33H29N3O5
StorageStoreat-20°C
Purity≥97%(HPLC)
CASNumber1338259-05-4
PubChemID53239854
InChIKeyIIJDFXNUWZTHIM-NRFANRHFSA-N
SmilesCC2=C(C)N(CC3=CC=C(C4=CC=CC=C4C(O)=O)C=C3)C1=CC=C(C(N[C@H](C5=CC=C([N+]([O-])=O)C=C5)C)=O)C=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO54.76100
ethanol54.76100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight547.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.83mL9.13mL18.26mL
5mM0.37mL1.83mL3.65mL
10mM0.18mL0.91mL1.83mL
50mM0.04mL0.18mL0.37mL