Broad-spectrumionchannelblocker;blockslateINa,ICa,IKrandIKsandincreasesQT.DisplaysclassIIIantiarrhythmicproperties.Alsoexhibitsfungicidalactivity;elicitsCa2+influxinSaccharomycescerevisiaeandcausesmitochondrialfragmentationandcelldeath.ThoughttostimulateautophagybytargetingupstreammTORC1controlpathways.SelectivelytoxictoNSCsinhESC-derivedcellpopulations.
AmiodaronehydrochlorideisalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 681.77 |
Formula | C25H29I2NO3.HCl |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 19774-82-4 |
PubChemID | 29770 |
InChIKey | ITPDYQOUSLNIHG-UHFFFAOYSA-N |
Smiles | CCCCC2=C(C(C3=CC(I)=C(OCCN(CC)CC)C(I)=C3)=O)C1=CC=CC=C1O2.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 13.64 | 20 |
Thefollowingdataisbasedontheproductmolecularweight681.77.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.47mL | 7.33mL | 14.67mL |
5mM | 0.29mL | 1.47mL | 2.93mL |
10mM | 0.15mL | 0.73mL | 1.47mL |
50mM | 0.03mL | 0.15mL | 0.29mL |