Na+channelblocker.DefinestheI2A-amiloridesensitiveandI2B-amilorideinsensitiveimidazolinebindingBlocksTRPP3,acidsensing-(ASIC)andmechanogatedmembrane-ionchannels,aswellastheNa+/H+exchanger.Alsoinhibitsurokinase-typeplasminogenactivator(uPA);hasnoeffectontissue-typeplasminogenactivator.
M.Wt | 266.09 |
Formula | C6H8ClN7O.HCl |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 2016-88-8 |
PubChemID | 16230 |
InChIKey | ACHKKGDWZVCSNH-UHFFFAOYSA-N |
Smiles | Cl.NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 26.61 | 100 | |
water | 2.66 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight266.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.76mL | 18.79mL | 37.58mL |
5mM | 0.75mL | 3.76mL | 7.52mL |
10mM | 0.38mL | 1.88mL | 3.76mL |
50mM | 0.08mL | 0.38mL | 0.75mL |