Functionallyuro-selectiveα1adrenoceptorantagonistthatdoesnotdiscriminatebetweenα1subtypes.Inhibitsincreasesinintraurethralpressurecausedbyphenylephrine-inducedcontractionby81%withminorcardiovasculareffects.Alsorelaxescorpuscavernosumtissue(pIC50=7.64)invitro.
| M.Wt | 425.91 |
| Formula | C19H27N5O4.HCl |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 81403-68-1 |
| PubChemID | 71764 |
| InChIKey | YTNKWDJILNVLGX-UHFFFAOYSA-N |
| Smiles | NC2=NC(N(C)CCCNC(C3CCCO3)=O)=NC1=CC(OC)=C(OC)C=C12.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.65 | 25 | |
| water | 10.65 | 25 |
Thefollowingdataisbasedontheproductmolecularweight425.91.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.35mL | 11.74mL | 23.48mL |
| 5mM | 0.47mL | 2.35mL | 4.7mL |
| 10mM | 0.23mL | 1.17mL | 2.35mL |
| 50mM | 0.05mL | 0.23mL | 0.47mL |



