HIF-prolylhydroxylase-2(PHD2)inhibitor.BlocksglutamateinducedROSproductioninHT-22cells,independentofMnSOD.Exhibitsneuroprotectiveeffectsandenhancesfunctionalrecoveryinrodentintracerebralhemorrhagemodels,viainhibitionofATF4dependentgenes.Brainpenetrant.Alsoantioxidant.
M.Wt | 377.82 |
Formula | C21H16ClN3O2 |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 385786-48-1 |
PubChemID | 3740671 |
InChIKey | KKYHNYRUBSYTCZ-UHFFFAOYSA-N |
Smiles | OC1=C(N=CC=C1)NC(C2=C(C3=C(C=C2)C=CC=N3)O)C4=CC=C(C=C4)Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 37.78 | 100 |
Thefollowingdataisbasedontheproductmolecularweight377.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.65mL | 13.23mL | 26.47mL |
5mM | 0.53mL | 2.65mL | 5.29mL |
10mM | 0.26mL | 1.32mL | 2.65mL |
50mM | 0.05mL | 0.26mL | 0.53mL |