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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Adaptaquin/5953/50/50 mg
产品编号:5953/50
市  场 价:¥11700.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$585.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Adaptaquin/5953/50/50 mg
商品介绍
Description:HIF-prolylhydroxylase-2(PHD2)inhibitor;antioxidant
ChemicalName:7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HIF-prolylhydroxylase-2(PHD2)inhibitor.BlocksglutamateinducedROSproductioninHT-22cells,independentofMnSOD.Exhibitsneuroprotectiveeffectsandenhancesfunctionalrecoveryinrodentintracerebralhemorrhagemodels,viainhibitionofATF4dependentgenes.Brainpenetrant.Alsoantioxidant.

TechnicalData

M.Wt377.82
FormulaC21H16ClN3O2
StorageStoreat-20°C
Purity≥97%(HPLC)
CASNumber385786-48-1
PubChemID3740671
InChIKeyKKYHNYRUBSYTCZ-UHFFFAOYSA-N
SmilesOC1=C(N=CC=C1)NC(C2=C(C3=C(C=C2)C=CC=N3)O)C4=CC=C(C=C4)Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO37.78100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight377.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.65mL13.23mL26.47mL
5mM0.53mL2.65mL5.29mL
10mM0.26mL1.32mL2.65mL
50mM0.05mL0.26mL0.53mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet