Antiviralagent,activeagainstherpessimplexvirusesHSV-1andHSV-2(EC50valuesare0.85and0.86μMrespectively).InterfereswithviralDNApolymerizationthroughcompetitiveinhibitionwithguanosinetriphosphate.InducesapoptosisincellstransfectedwithHSV-TK(suicidalgenetherapy).
AcyclovirisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 225.21 |
Formula | C8H11N5O3 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 59277-89-3 |
PubChemID | 2022 |
InChIKey | MKUXAQIIEYXACX-UHFFFAOYSA-N |
Smiles | NC1=NC(=O)C2=C(N1)N(COCCO)C=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.HCl | 11.26 | 50 | |
DMSO | 4.5 | 20 |
Thefollowingdataisbasedontheproductmolecularweight225.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.44mL | 22.2mL | 44.4mL |
5mM | 0.89mL | 4.44mL | 8.88mL |
10mM | 0.44mL | 2.22mL | 4.44mL |
50mM | 0.09mL | 0.44mL | 0.89mL |