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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AZ 12080282 dihydrochloride/4838/10/10 mg
产品编号:4838/10
市  场 价:¥4380.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$219.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AZ 12080282 dihydrochloride/4838/10/10 mg
商品介绍
Description:InhibitorofHedgehog(Hh)signaling
ChemicalName:N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamidedihydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofHedgehog(Hh)signaling(IC50<0.012μMinafireflyreporterassayagainsttheHhpathway).ShowntodisplacecyclopamineinHeLacellsexpressingSmoothened.Exhibitsselectivityagainstp38α.Orallybioavailable.

LicensingInformation

SoldwiththepermissionofAstraZenecaUKLtd.

CompoundLibraries

AZ12080282dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt457.35
FormulaC23H20N4O2.2HCl
StorageDesiccateatRT
Purity≥98%(HPLC)
PubChemID78243727
InChIKeyCPORFOBFIDPDLZ-UHFFFAOYSA-N
SmilesCC1=CC=C(C2=NC=CN2)C=C1NC(C3=CC=C(OCC4=CC=CC=N4)C=C3)=O.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO45.73100
water45.73100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight457.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.19mL10.93mL21.87mL
5mM0.44mL2.19mL4.37mL
10mM0.22mL1.09mL2.19mL
50mM0.04mL0.22mL0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet