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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/ARL 17477 dihydrochloride/3319/50/50 mg
产品编号:3319/50
市  场 价:¥11700.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$585.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/ARL 17477 dihydrochloride/3319/50/50 mg
商品介绍
Description:SelectivenNOSinhibitor
ChemicalName:N-[4-[2-[[(3-Chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboxamidedihydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectiveneuronalnitrogenoxidesynthase(nNOS)inhibitor(IC50valuesare1and17μMfornNOSandendothelialNOSrespectively).Reducesischemiccelldamageaftermiddlecerebralartery(MCA)occlusioninrats.DisplaysasynergisticneuroprotectiveeffectwhencombinedwitheitheranNMDAorAMPAreceptorantagoNIST.

LicensingInformation

SoldwiththepermissionofAstraZenecaUKLtd.

TechnicalData

M.Wt442.83
FormulaC20H20ClN3S.2HCl
StorageDesiccateatRT
Purity≥99%(HPLC)
CASNumber866914-87-6
PubChemID9824646
InChIKeySOXBYIKSUDXMIE-UHFFFAOYSA-N
SmilesClC1=CC=CC(CNCCC2=CC=C(NC(C3=CC=CS3)=N)C=C2)=C1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO44.28100
water22.1450

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight442.83.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.26mL11.29mL22.58mL
5mM0.45mL2.26mL4.52mL
10mM0.23mL1.13mL2.26mL
50mM0.05mL0.23mL0.45mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet