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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/2-APB/1224/50/50 mg
产品编号:1224/50
市  场 价:¥4980.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$249.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/2-APB/1224/50/50 mg
商品介绍
Description:IP3receptorantagoNIST.AlsoTRPchannelmodulator
ChemicalName:2-Aminoethoxydiphenylborane
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

AfunctionalandmembranepermeableD-myo-inositol1,4,5-trisphosphate(IP3)receptorantagonist(IC50=42μM).Stimulatesstore-operatedcalcium(SOC)releaseatlowconcentrations(<10μM)andinhibitsitathigherconcentrations(upto50μM).IncreasesSTIM-Oraichannelconductanceandlimitsionselectivity.ModulatorofTRPchannels;blocksTRPC1,TRPC3,TRPC5,TRPC6,TRPV6,TRPM3,TRPM7,TRPM8andTRPP2andathigherconcentrationsstimulatesTRPV1,TRPV2andTRPV3.Alsoblocksspecificgapchannelsubtypes.

TechnicalData

M.Wt225.1
FormulaC14H16BNO
StorageStoreatRT
Purity≥98%(HPLC)
CASNumber524-95-8
PubChemID1598
InChIKeyBLZVCIGGICSWIG-UHFFFAOYSA-N
SmilesNCCOB(C1=CC=CC=C1)C1=CC=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO22.51100mMwithgentlewarming
ethanol2.2510mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight225.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.44mL22.21mL44.42mL
5mM0.89mL4.44mL8.88mL
10mM0.44mL2.22mL4.44mL
50mM0.09mL0.44mL0.89mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet