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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AK 7/4754/10/10 mg
产品编号:4754/10
市  场 价:¥2780.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$139.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AK 7/4754/10/10 mg
商品介绍
Description:SelectiveSIRT2inhibitor;brainpenetrant
ChemicalName:N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]benzamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveSIRT2inhibitor(IC50=15.5μM);displaysnoeffectonSIRT1orSIRT3.Decreasesneuronalcholesterollevels;improvesmotorfunctionandamelioratesbrainatrophyinamousemodelofHuntington'sdisease.Brainpenetrant.

CompoundLibraries

AK7isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt437.35
FormulaC19H21BrN2O3S
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber420831-40-9
PubChemID1328033
InChIKeyIYAYHZZWYNXHEQ-UHFFFAOYSA-N
SmilesO=C(NC2=CC(Br)=CC=C2)C1=CC(S(N3CCCCCC3)(=O)=O)=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO43.73100
ethanol4.3710mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight437.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.29mL11.43mL22.86mL
5mM0.46mL2.29mL4.57mL
10mM0.23mL1.14mL2.29mL
50mM0.05mL0.23mL0.46mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet