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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AC 5216/5281/50/50 mg
产品编号:5281/50
市  场 价:¥13700.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$685.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AC 5216/5281/50/50 mg
商品介绍
Description:SelectiveTSPOligand
AlternativeNames:XBD173
ChemicalName:N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Ligandoftranslocatorprotein(TSPO,peripheralbenzodiazepinereceptor).ExhibitshighaffinityforTSPOinratwholebrain(Ki=0.297nM),andhighpotencyagainsthumanandratglialTSPO(IC50valuesare2.73and3.04nMrespectively).Displaysnonoticeablebindingtoanumberofotherreceptors,transportersorionchannels.Alsodisplaysanxiolyticandantidepressanteffectsinrodentmodels,withoutinducingbenzodiazepine-likeadverseeffects.

CompoundLibraries

AC5216isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt401.46
FormulaC23H23N5O2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber226954-04-7
PubChemID6433109
InChIKeyNBMBIEOUVBHEBM-UHFFFAOYSA-N
SmilesO=C(N1C)N(CC(N(CC)CC2=CC=CC=C2)=O)C3=C1C=NC(C4=CC=CC=C4)=N3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO40.15100
ethanol4.0110mMwithsonication

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight401.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.49mL12.45mL24.91mL
5mM0.5mL2.49mL4.98mL
10mM0.25mL1.25mL2.49mL
50mM0.05mL0.25mL0.5mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet