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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/A01/5397/50/50 mg
产品编号:5397/50
市  场 价:¥12580.00
场      地:美国(厂家直采)
产品分类: 分子类>核酸酶类>连接酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$629.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/A01/5397/50/50 mg
商品介绍
Description:HighaffinitySmurf1inhibitor;enhancesBMPsignaling
ChemicalName:[4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighaffinitySmurf1E3ubiquitinligaseinhibitor(Kd=3.7nM).AttenuatesSmurf1-mediatedSmad1/5degradationandenhancesBMPsignaling.PotentiatesBMP-2-inducedosteoblasticactivityinC2C12myoblastsandMC3T3-E1osteoblastprecursorcells.

TechnicalData

M.Wt512.93
FormulaC22H20ClF3N4O3S
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber1007647-73-5
PubChemID17555704
InChIKeyQFYLTUDRXBNZFQ-UHFFFAOYSA-N
SmilesClC1=C(C(F)(F)F)C=C(S(N2CCN(C(C3=CC=C(N4C(C)=CC=N4)C=C3)=O)CC2)(=O)=O)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO51.29100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight512.93.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.95mL9.75mL19.5mL
5mM0.39mL1.95mL3.9mL
10mM0.19mL0.97mL1.95mL
50mM0.04mL0.19mL0.39mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet