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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/A 987306/3640/10/10 mg
产品编号:3640/10
市  场 价:¥4700.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$235.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/A 987306/3640/10/10 mg
商品介绍
Description:PotentandselectiveH4receptorantagoNIST
ChemicalName:(±)-(7aR*,11aR*)-5,6,7a,8,9,10,11,11a-Octahydro-4-(1-piperazinyl)-benzofuran[2,3-h]quinazolin-2-amine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotenthistamineH4receptorantagonist(pKivaluesare8.24and8.47inhumanandratH4receptorsrespectively).Displays162-fold,620-fold,and>1600-foldselectivityoverhumanH3,H1andH2receptors.Blockszymosan-inducedneutrophilrefluxandattenuatesthermalhypersensitivityinvivo(ED50=42μmol/kg,ip).

CompoundLibraries

A987306isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt327.42
FormulaC18H25N5O
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1082954-71-9
PubChemID25109291
InChIKeyDJKJVWJQAVGLHJ-YPMHNXCESA-N
SmilesNC3=NC1=C(C(N4CCNCC4)=N3)CCC2=C1[C@@](CCCC5)([H])[C@@]5([H])O2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO32.74100
ethanol32.74100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight327.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.05mL15.27mL30.54mL
5mM0.61mL3.05mL6.11mL
10mM0.31mL1.53mL3.05mL
50mM0.06mL0.31mL0.61mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet