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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/A 922500/3587/10/10 mg
产品编号:3587/10
市  场 价:¥6180.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$309.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/A 922500/3587/10/10 mg
商品介绍
Description:PotentDGAT-1inhibitor
AlternativeNames:DGAT-1Inhibitor4a
ChemicalName:(1R,2R)-2-[[4'-[[Phenylamino)carbonyl]amino][1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Diacylglycerolacyltransferase1(DGAT-1)inhibitor(IC50valuesare7and24nMathumanandmouseDGAT-1respectively)thatisdevoidofactivityatDGAT-2,ACAT1orACAT2.Inducessignificantweightlosswithoutalteringfoodintake,anddecreasesliverandplasmatriglyceridelevelsinvivo.Orallyactive.

CompoundLibraries

A922500isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt428.48
FormulaC26H24N2O4
StorageDesiccateat+4°C
Purity≥98%(HPLC)
CASNumber959122-11-3
PubChemID24768261
InChIKeyBOZRFEQDOFSZBV-DHIUTWEWSA-N
SmilesO=[C@]([C@@H]3CCC[C@H]3[C@@](O)=O)C(C=C2)=CC=C2C1=CC=C(NC(NC4=CC=CC=C4)=O)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO21.4250

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight428.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.33mL11.67mL23.34mL
5mM0.47mL2.33mL4.67mL
10mM0.23mL1.17mL2.33mL
50mM0.05mL0.23mL0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet