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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/A 366/5163/50/50 mg
产品编号:5163/50
市  场 价:¥15300.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$765.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/A 366/5163/50/50 mg
商品介绍
Description:PotentandselectiveG9a/GLPinhibitor
ChemicalName:5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveG9a/GLPhistonelysinemethyltransferaseinhibitor(IC50=3.3nM).Exhibits>1000-foldselectivityforG9a/GLPover21othermethyltransferases.Decreaseslevelsoflysine9dimethylationonhistoneH3(H3K9Me2)inPC3cells.

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheA366probesummaryontheSGCwebsite.

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofA366isreviewedonthechemicalprobeswebsite.

CompoundLibraries

A366isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt329.44
FormulaC19H27N3O2
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1527503-11-2
PubChemID76285486
InChIKeyBKCDJTRMYWSXMC-UHFFFAOYSA-N
SmilesCOC1=C(OCCCN4CCCC4)C=C(N=C(N)C32CCC3)C2=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.HCl32.94100
DMSO32.94100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight329.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.04mL15.18mL30.35mL
5mM0.61mL3.04mL6.07mL
10mM0.3mL1.52mL3.04mL
50mM0.06mL0.3mL0.61mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet