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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/NMS 873/6180/50/50 mg
产品编号:6180/50
市  场 价:¥13380.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$669.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/NMS 873/6180/50/50 mg
商品介绍
Description:Potentandselectivep97ATPase(VCP)allostericinhibitor
ChemicalName:3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentp97ATPase(VCP)allostericinhibitor(IC50=30nM).SelectiveoverallotherAAAATPases,HSP90andkinasestested(IC50>10μM).Activatestheunfoldedproteinresponse(UPR)andmodulatesautophagosomematuration.Exhibitsantiproliferativeactivityincancercellsinvitro(IC50valuesare400and700nMforHCT116andHeLacellsrespectively).Reducesp97-sensitizationtotrypsindigestion.

CompoundLibraries

NMS873isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt520.67
FormulaC27H28N4O3S2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber1418013-75-8
PubChemID71521142
InChIKeyUJGTUKMAJVCBIS-UHFFFAOYSA-N
SmilesCC1=C(C2=CC=C(S(C)(=O)=O)C=C2)C=CC(OCC3=NN=C(N3C4=CN=CC=C4)SC5CCCC5)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO52.07100
ethanol5.2110mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight520.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.92mL9.6mL19.21mL
5mM0.38mL1.92mL3.84mL
10mM0.19mL0.96mL1.92mL
50mM0.04mL0.19mL0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet