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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/OTX 015/6181/50/50 mg
产品编号:6181/50
市  场 价:¥23980.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$1199.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/OTX 015/6181/50/50 mg
商品介绍
Description:BETbromodomaininhibitor;orallybioavailable
ChemicalName:(6S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

BETbromodomaininhibitor(IC50valuesareintherange92-112nM).Inhibitsproliferationandinducesapoptosisofleukemiacelllinesinvitro.DecreasesBRD2,BRD4andc-MYCproteinexpression.Orallybioavailable.

TechnicalData

M.Wt491.99
FormulaC25H22ClN5O2S
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber202590-98-5
PubChemID9936746
InChIKeyGNMUEVRJHCWKTO-FQEVSTJZSA-N
SmilesCC1=C(C2=C(N3C(C)=NN=C3[C@@H](N=C2C4=CC=C(C=C4)Cl)CC(NC5=CC=C(C=C5)O)=O)S1)C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO49.2100
ethanol9.8420

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight491.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.03mL10.16mL20.33mL
5mM0.41mL2.03mL4.07mL
10mM0.2mL1.02mL2.03mL
50mM0.04mL0.2mL0.41mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet