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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Zoledronic Acid/6111/10/10 mg
产品编号:6111/10
市  场 价:¥1380.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$69.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Zoledronic Acid/6111/10/10 mg
商品介绍
Description:Potentfarnesyldiphosphate(FPP)synthaseinhibitor
AlternativeNames:Zometa
ChemicalName:[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentbisphophonatefarnesyldiphosphate(FPP)synthaseinhibitor(IC50=20nM).Inhibitsosteoclast-mediatedboneresorption.AlsoinhibitsRassignalingandtumorgrowth,andinducesapoptosisinpancreaticcancercells.Reversesepithelial-mesenchymaltransitionandinhibitsbreastcancercellrenewalviainactivationofNF-κB.

TechnicalData

M.Wt272.09
FormulaC5H10N2O7P2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber118072-93-8
PubChemID68740
InChIKeyXRASPMIURGNCCH-UHFFFAOYSA-N
SmilesOC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
water0.682.5
1.1eq.NaOH13.650

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight272.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.68mL18.38mL36.75mL
5mM0.74mL3.68mL7.35mL
10mM0.37mL1.84mL3.68mL
50mM0.07mL0.37mL0.74mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet