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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/ZM 306416 hydrochloride/2499/1/1 mg
产品编号:2499/1
市  场 价:¥1900.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>激酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$95.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/ZM 306416 hydrochloride/2499/1/1 mg
商品介绍
Description:InhibitorofVEGFreceptortyrosinekinase
ChemicalName:4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazolinehydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Inhibitorofvascularendothelialgrowthfactor(VEGF)receptortyrosinekinase.InhibitsactivityofKDRandFLTVEGFreceptors(IC50valuesare100nMand2μMrespectively)anddisplays>3-foldselectivityoverFGFR-1.Orallyactiveinvivo.

LicensingInformation

SoldwiththepermissionofAstraZenecaUKLtd.

TechnicalData

M.Wt370.21
FormulaC16H13N3O2FCl.HCl
StorageDesiccateatRT
Purity≥99%(HPLC)
CASNumber196603-47-1
PubChemID21701577
InChIKeySCUXIROMWPQVJO-UHFFFAOYSA-N
SmilesCl.COC1=C(OC)C=C2C(NC3=CC=C(Cl)C=C3F)=NC=NC2=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO3.710

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight370.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.7mL13.51mL27.01mL
5mM0.54mL2.7mL5.4mL
10mM0.27mL1.35mL2.7mL
50mM0.05mL0.27mL0.54mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet