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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/ZIP/2549/1/1 mg
产品编号:2549/1
市  场 价:¥3980.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$199.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/ZIP/2549/1/1 mg
商品介绍
Description:Cell-permeableinhibitorofatypicalPKCisozymePKMζ
AlternativeNames:z-Pseudosubstrateinhibitorypeptide
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Novel,cell-permeableinhibitorofproteinkinaseMζ(PKMζ),aconstitutivelyactive,atypicalPKCisozymeinvolvedinLTPmaintenance.SelectivelyblocksPKMζ-inducedsynapticpotentiationinhippocampalslicesinvitro.Reverseslate-phaseLTP(IC50=1-2.5μM)andproducespersistentlossof1-day-oldspatialmemoryfollowingcentraladmiNISTrationinvivo.Controlandbiotinylatedpeptides(Cat.Nos.3215and3290)alsoavailable.

TechnicalData

M.Wt1982.4
FormulaC90H154N30O17
SequenceSIYRRGARRWRKL

(Modifications:Ser-1=Myr-Ser)

StorageDesiccateat-20°C
CASNumber863987-12-6
PubChemID16156119
InChIKeyCRKARHQCXWSUMV-HOHDCHNJSA-N
Smiles[H]N([C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)CCCCCCCCCCCCC

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight1982.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.5mL2.52mL5.04mL
5mM0.1mL0.5mL1.01mL
10mM0.05mL0.25mL0.5mL
50mM0.01mL0.05mL0.1mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet