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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/YM 90709/1675/10/10 mg
产品编号:1675/10
市  场 价:¥4100.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$205.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/YM 90709/1675/10/10 mg
商品介绍
Description:Interleukin-5receptorantagoNIST
ChemicalName:5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-b]quinoxaline
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Novel,selectiveinhibitorofinterleukin-5(IL-5)(IC50=0.45-1mM).InhibitsIL-5-prolongedeosinophilsurvivalandIL-5-inducedtyrosinephosphorylationofJAK2withoutinhibitingGM-CSF-mediatedeffects.Inhibitsantigen-inducedeosinophilandlymphocyterecruitmentinratairwaysinvivo,withoutaffectingperipheralbloodorbonemarrowleukocytes.

LicensingInformation

SoldwiththepermissionofAstellasPharmaInc.

TechnicalData

M.Wt359.43
FormulaC22H21N3O2
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber163769-88-8
PubChemID1103147
InChIKeyHIXSPVQXXDULHS-UHFFFAOYSA-N
SmilesCOC1=CC2=C(C=C1OC)C1=CC3=NC4=CC=CC=C4N=C3N1C(C)(C)C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO17.9750
ethanol8.9925

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight359.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.78mL13.91mL27.82mL
5mM0.56mL2.78mL5.56mL
10mM0.28mL1.39mL2.78mL
50mM0.06mL0.28mL0.56mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet