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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/YM 58483/3939/50/50 mg
产品编号:3939/50
市  场 价:¥16500.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$825.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/YM 58483/3939/50/50 mg
商品介绍
Description:InhibitorofSOCEinnon-excitablecells
AlternativeNames:Btp2
ChemicalName:N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiADIazole-5-carboxamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Blockerofstore-operatedCa2+entry(SOCE),whichmediatestheactivationofnon-excitablecells(e.g.lymphocytes).Inhibitscalciumrelease-activatedcalcium(CRAC)channels;suppressesthapsigargin-inducedsustainedCa2+influx(IC50=100nM).Displaysimmuno-modulatoryandanti-inflammatoryeffects;suppressescytokineproductionandproliferationofTcellsinvitro.

CompoundLibraries

YM58483isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt421.32
FormulaC15H9F6N5OS
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber223499-30-7
PubChemID2455
InChIKeyXPRZIORDEVHURQ-UHFFFAOYSA-N
SmilesO=C(C3=C(C)N=NS3)NC1=CC=C(N2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO42.13100
ethanol42.13100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight421.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.37mL11.87mL23.73mL
5mM0.47mL2.37mL4.75mL
10mM0.24mL1.19mL2.37mL
50mM0.05mL0.24mL0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet