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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/XL 184/5422/10/10 mg
产品编号:5422/10
市  场 价:¥3980.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>激酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$199.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/XL 184/5422/10/10 mg
商品介绍
Description:PotentVEGFRinhibitor;alsoinhibitsotherRTKs
AlternativeNames:Cabozantinib,BMS907351
ChemicalName:N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentVEGFRinhibitor(IC50=0.035nM);alsoinhibitsc-Met,KIT,RET,FLT4,AXL,FLT3,FLT1andTie2(IC50valuesare1.3,4.6,5.2,6,7,11.3,12and14.3nM,respectively).Inducesintratumoralhypoxiaandapoptosis.Reducestumorinvasionandmetastasisinvivo.Antiangiogenic.

CompoundLibraries

XL184isalsoofferedaspartoftheTocriscreenKinaseInhibitorToolboxIIandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt501.51
FormulaC28H24FN3O5
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber849217-68-1
PubChemID25102847
InChIKeyONIQOQHATWINJY-UHFFFAOYSA-N
SmilesCOC1=CC2=C(C=C1OC)N=CC=C2OC3=CC=C(NC(C4(CC4)C(NC5=CC=C(F)C=C5)=O)=O)C=C3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO50.15100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight501.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.99mL9.97mL19.94mL
5mM0.4mL1.99mL3.99mL
10mM0.2mL1mL1.99mL
50mM0.04mL0.2mL0.4mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet