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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/XAV 939/3748/50/50 mg
产品编号:3748/50
市  场 价:¥14100.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$705.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/XAV 939/3748/50/50 mg
商品介绍
Description:Potenttankyraseinhibitor
ChemicalName:3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potenttankyrase(TNKS)inhibitor(IC50valuesare4and11nMforTNKS2andTNKS1respectively).AntagonizesWntsignalingviastimulationofβ-catenindegradationandstABIlizationofaxin.Inhibitsproliferationoftheβ-catenin-dependentcoloncarcinomacelllineDLD-1.PromotescardiomyogenicdevelopmentinmesodermProgenitorcells.

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofXAV939isreviewedonthechemicalprobeswebsite.

CompoundLibraries

XAV939isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt312.31
FormulaC14H11F3N2OS
StorageStoreatRT
Purity≥98%(HPLC)
CASNumber284028-89-3
PubChemID2726824
InChIKeyKLGQSVMIPOVQAX-UHFFFAOYSA-N
SmilesOC1=C(CSCC2)C2=NC(C3=CC=C(C(F)(F)F)C=C3)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO6.2520

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight312.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.2mL16.01mL32.02mL
5mM0.64mL3.2mL6.4mL
10mM0.32mL1.6mL3.2mL
50mM0.06mL0.32mL0.64mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet