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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Vatalanib succinate/5680/10/10 mg
产品编号:5680/10
市  场 价:¥2380.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>激酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$119.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Vatalanib succinate/5680/10/10 mg
商品介绍
Description:PotentVEGFRinhibitor;alsoaromataseinhibitor
AlternativeNames:CGP79787D,PTK787/ZK222584
ChemicalName:N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinaminesuccinate
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentVEGFRinhibitor(IC50valuesare37and77nMforVEGFR-2and-1,respectively).Inhibitsproliferation,migrationandsurvivalofHUVECsinvitroandinhibitsgrowth,vascularizationandmetastasisoftumorsexpressingVEGFRinmousemodels.AlsoinhibitsPDGFR-β,c-Kitandc-Fms.Potentaromataseinhibitor(IC50=50nM).Orallyavailable.

CompoundLibraries

VatalanibsuccinateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt464.9
FormulaC20H15ClN4.C4H6O4
StorageStoreat-20°C
Purity≥99%(HPLC)
CASNumber212142-18-2
PubChemID151193
InChIKeyLLDWLPRYLVPDTG-UHFFFAOYSA-N
SmilesClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42.OC(CCC(O)=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO46.49100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight464.9.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.15mL10.76mL21.51mL
5mM0.43mL2.15mL4.3mL
10mM0.22mL1.08mL2.15mL
50mM0.04mL0.22mL0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet