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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/UNC 1215/4666/50/50 mg
产品编号:4666/50
市  场 价:¥18100.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$905.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/UNC 1215/4666/50/50 mg
商品介绍
Description:PotentinhibitorofL3MBTL3Kmereaderdomain;cellpermeable
ChemicalName:2-Phenylamino-1,4-[4-(pyrrolidinyl)piperidinyl)benzamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentinhibitorofL3MBTL3methyllysine(Kme)readerdomain(IC50=40nM;Kd=120nM).Displays>100-foldselectivityoverapanelofhistonemethyltransferases,kinases,ionchannelsand7-TMreceptors.Disruptssubnuclearlocalizationandfociformationoffluorescently-labeledL3MBTL3inHEK293cells.

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheUNC1215probesummaryontheSGCwebsite.

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofUNC1215isreviewedonthechemicalprobeswebsite.

CompoundLibraries

UNC1215isalsoofferedaspartoftheTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt529.72
FormulaC32H43N5O2
StorageStoreat-20°C
Purity≥99%(HPLC)
PubChemID57339144
InChIKeyPQOOIERVZAXHBP-UHFFFAOYSA-N
SmilesO=C(N2CCC(N3CCCC3)CC2)C1=C(NC6=CC=CC=C6)C=C(C(N4CCC(N5CCCC5)CC4)=O)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
2eq.HCl52.97100
DMSO26.4950
ethanol52.97100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight529.72.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.89mL9.44mL18.88mL
5mM0.38mL1.89mL3.78mL
10mM0.19mL0.94mL1.89mL
50mM0.04mL0.19mL0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet