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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/A 196/6167/50/50 mg
产品编号:6167/50
市  场 价:¥10100.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$505.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/A 196/6167/50/50 mg
商品介绍
Description:PotentandselectiveSUV420H1/H2inhibitor
ChemicalName:6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveSUV420H1/H2inhibitor(IC50valuesare25and144nMrespectively).Exhibits100-foldselectivityoverotherhistonemethyltransferasesandnon-epigenetictargets.Inhibitsthedi-andtri-methylationofH4K20meinmultiplecelllines(IC50<1μM).

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheA-196probesummaryontheSGCwebsite.

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofA196isreviewedontheChemicalProbeswebsite.

TechnicalData

M.Wt359.25
FormulaC18H16Cl2N4
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber1982372-88-2
SmilesClC1=CC2=C(C(C3=CC=NC=C3)=NN=C2NC4CCCC4)C=C1Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO7.1820

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight359.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.78mL13.92mL27.84mL
5mM0.56mL2.78mL5.57mL
10mM0.28mL1.39mL2.78mL
50mM0.06mL0.28mL0.56mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet