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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/TC-I 15/4527/50/50 mg
产品编号:4527/50
市  场 价:¥18500.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$925.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/TC-I 15/4527/50/50 mg
商品介绍
Description:Potentα2β1inhibitor;displaysantithromboticactivityinvivo
ChemicalName:N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentα2β1integrininhibitor(IC50valuesfortheinhibitionofhumanplateletadhesiontotypeIcollagenare12and715nMforplateletsunderstaticconditionsandunderflow,respectively).Displaysselectivityforα2β1overαvβ3,α5β1,α6β1andαIIbβ3atconcentrationsexceeding1000nM.ReducescollagenIVproductioninmesangialcells.Activeinvivo;preventsferricchloride-inducedclotformationinmice.

LicensingInformation

SoldunderlicensefromtheUniversityofPennsylvania.

CompoundLibraries

TC-I15isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt520.62
FormulaC23H28N4O6S2
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber916734-43-5
PubChemID90488948
InChIKeyXKLHCUGVLCGKKX-RBUKOAKNSA-N
SmilesCC1(C)SCN(S(C3=CC=CC=C3)(=O)=O)[C@@H]1[C@@](N[C@H](C(O)=O)CNC(NCC2=CC=CC=C2)=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1.1eq.NaOH13.0225
DMSO52.06100
ethanol52.06100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight520.62.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.92mL9.6mL19.21mL
5mM0.38mL1.92mL3.84mL
10mM0.19mL0.96mL1.92mL
50mM0.04mL0.19mL0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet