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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SB 431542/1614/1/1 mg
产品编号:1614/1
市  场 价:¥2500.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$125.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SB 431542/1614/1/1 mg
商品介绍
Description:Potent,selectiveinhibitorofTGF-βRI,ALK4andALK7
ChemicalName:4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectiveinhibitorofthetransforminggrowthfactor-β(TGF-β)typeIreceptoractivinreceptor-likekinaseALK5(IC50=94nM),anditsrelativesALK4andALK7.SuppressesTGF-β-inducedproliferationofhumanosteosarcomacells.Stimulatesproliferation,differentiationandsheetformationofESC-derivedendothelialcells.InhibitsTGF-β-inducedEMT,migration,invasionandVEGFsecretioninseveralhumancancercelllines.

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline

CompoundLibraries

SB431542isalsoofferedaspartoftheTocriscreenPlus,TocriscreenKinaseInhibitorToolboxIandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt384.39
FormulaC22H16N4O3
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber301836-41-9
PubChemID4521392
InChIKeyFHYUGAJXYORMHI-UHFFFAOYSA-N
SmilesNC(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=CC=N1)C1=CC2=C(OCO2)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO38.44100
ethanol3.8410

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight384.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.6mL13.01mL26.02mL
5mM0.52mL2.6mL5.2mL
10mM0.26mL1.3mL2.6mL
50mM0.05mL0.26mL0.52mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet