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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Ro 08-2750/2272/50/50 mg
产品编号:2272/50
市  场 价:¥15100.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>激酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$755.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Ro 08-2750/2272/50/50 mg
商品介绍
Description:InhibitsNGFbindingtop75NTRandTrkA
ChemicalName:2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
Purity:≥95%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Non-peptideinhibitorofNGFthatbindstheNGFdimer(KD~1μM)possIBLycausingaconformationalchange.SelectivelyinhibitsbindingofNGFtop75NTRatsubmicromolarconcentrations,andtobothp75NTRandTrkAatconcentrations>5μM.PreventsNGF-inducedapoptosisinSK-N-MCcells.

TechnicalData

M.Wt270.24
FormulaC13H10N4O3
StorageStoreat-20°C
Purity≥95%(HPLC)
CASNumber37854-59-4
PubChemID17756791
InChIKeyJDEMVNYMYPJJIM-UHFFFAOYSA-N
SmilesCN1C2=CC(C=O)=C(C)C=C2N=C2C(=O)NC(=O)N=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.NaOH13.5150
DMSO2.710mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight270.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.7mL18.5mL37mL
5mM0.74mL3.7mL7.4mL
10mM0.37mL1.85mL3.7mL
50mM0.07mL0.37mL0.74mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet