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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Rifaximin/5359/50/50 mg
产品编号:5359/50
市  场 价:¥980.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$49.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Rifaximin/5359/50/50 mg
商品介绍
Description:PregnaneXreceptoragoNIST;antibiotic
ChemicalName:(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PregnaneXreceptor(PXR)agonist;antibiotic.ReducesnumberofcolontumorsandsuppressesexpressionofTNFαandIl-1βinducedinacoloncancer,PXR-humanizedmousemodel.IncreasesapoptosisanddecreasedproliferationinHT-29cells.Exhibitslowgastrointestinalabsorptionwhileretainingitsantibacterialactivity.Activeagainstgram-positiveandgram-negativebacteria.

TechnicalData

M.Wt785.88
FormulaC43H51N3O11
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber80621-81-4
PubChemID6436173
InChIKeyNZCRJKRKKOLAOJ-XRCRFVBUSA-N
SmilesO=C(/C(C)=CC=C[C@H](C)[C@H](O)[C@H]([C@H]([C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@@]5(C)O4)O)C)NC2=C(O)C1=C(O)C(C)=C4C(C5=O)=C1C3=C2N6C(C=C(C)C=C6)=N3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO78.59100
ethanol78.59100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight785.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.27mL6.36mL12.72mL
5mM0.25mL1.27mL2.54mL
10mM0.13mL0.64mL1.27mL
50mM0.03mL0.13mL0.25mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet