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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/RepSox/3742/50/50 mg
产品编号:3742/50
市  场 价:¥14100.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$705.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/RepSox/3742/50/50 mg
商品介绍
Description:PotentandselectiveinhibitorofTGF-βRI
AlternativeNames:E-616452,SJN2511,ALK5InhibitorII
ChemicalName:2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveinhibitoroftheTGF-βtypeIreceptor/ALK5(IC50valuesare4and23nMforTGF-βtypeIreceptorautophosphorylationandbindingrespectively).SelectiveforTGF-βtypeIreceptoroverarangeofkinases,includingp38MAPK,JNK1andGSK3(IC50>16μM).Enhancestheefficiencyofcellularreprogramming;replacesSox2byinducingNanogexpression.

CompoundLibraries

RepSoxisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt287.32
FormulaC17H13N5
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber446859-33-2
PubChemID449054
InChIKeyLBPKYPYHDKKRFS-UHFFFAOYSA-N
SmilesCC1=NC(C2=NNC=C2C4=NC3=CC=CN=C3C=C4)=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO28.73100
ethanol14.3750

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight287.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.48mL17.4mL34.8mL
5mM0.7mL3.48mL6.96mL
10mM0.35mL1.74mL3.48mL
50mM0.07mL0.35mL0.7mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet